The most challenging aspect of treating alcohol and drug addiction is the relapsing course of
these disorders. Although substitution therapies for nicotine and opioid dependence have
proven to be relatively effective, there is a need for new pharmacotherapies designed to
decrease the frequency and severity of relapse. The aim of this paper is to provide an
overview of the potential utility of N-methyl-d-aspartate (NMDA) receptor antagonists as
treatments for substance abuse as shown in preclinical models and preliminary clinical …